RAF Typhoon jets have operated alongside French aircraft in a coordinated attack targeting an hidden munitions depot in Syrian territory used by the IS group, according to the British defence ministry.
The facility, pinpointed through surveillance, was believed to be storing arms and explosives, the announcement noted, and was situated in mountains just above the historic site of Palmyra in central Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to hit a number of approach shafts providing entry to the depot... early reports suggest the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the operation conducted Saturday night and each participating jet returned safely, the ministry further stated.
The British jets were supported by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - imposed extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike shows the UK's leading role, and determination to stand shoulder to shoulder with our partners, to eradicate any re-emergence of IS and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed patrols over Syrian airspace to "prevent any attempted comeback" of Islamic State following its defeat at the battle of Baghuz in the year 2019, the authorities noted.
"I must thank every member of British forces who took part in this operation for their professionalism and their valour," he added. "They were part of numerous British personnel deployed over the festive period. This operation, to eliminate dangerous terrorists who threaten our security, highlights how UK forces are prepared to act, throughout the year, ensuring Britain's security domestically and strong abroad."
During December, the United States armed forces executed what it described as a "large-scale strike" on Daesh sites in Syria, after an ambush killed two US troops and a civilian interpreter in Palmyra.
The United Nations says Islamic State still boasts between 5,000 and 7,000 combatants in Iraq and Syria.